Striatin-Dependent Membrane Estrogen Receptor Signaling and Vasoprotection by Estrogens Running title: Bobik; Membrane Estrogen Receptor Signaling
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چکیده
Ad Addr dr res es ess s s fo fo for r Co Co orr rr rre es espo po pond nd nde ence ce e: : : Professor Al Al lex ex exan an ande de der r r Bo Bo Bobi b k k k
منابع مشابه
Striatin-dependent membrane estrogen receptor signaling and vasoprotection by estrogens.
It is well known that cardiovascular disease is less frequent in premenopausal women compared with men but rises rapidly in postmenopausal women. Such early observations led to the hypothesis that estrogen therapy will reduce the risk of postmenopausal women developing cardiovascular disease.1 However, observational studies have led to conflicting results, with some studies reporting reductions...
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Steroid hormone receptors (SHRs) are ligand-activated transcription factors that regulate gene expression. SHRs also mediate rapid, nongenomic cellular activation by steroids. In vascular endothelial cells, the SHR for estrogen, estrogen receptor (ER) alpha, is targeted by unknown mechanisms to a functional signaling module in membrane caveolae that enables estrogen to rapidly activate the mito...
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Estrogen has multiple actions in the brain to modulate homeostasis, synaptic plasticity/cognition and neuroprotection. While many of these actions undoubtedly involve mediation via the classical genomic mechanism of regulation of transcription of genes via estrogen nuclear receptors, there has been growing interest in the rapid nongenomic effects of estrogen and the role they may play in the ne...
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Recognition of the complexity of estrogen and estrogen receptor (ER) signaling has substantially increased in the last several years. In their genomic role, estrogens enter the cell and bind to ERs which are members of a superfamily of ligand-regulated transcription factors. However, estrogens also exert non-genomic effects that occur independently of gene transcription. Typically, these relati...
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تاریخ انتشار 2012